What Trimesan is and what it is used for
Trimesan is an antibacterial medicine for internal use. The active substance is trimethoprim which is an inhibitor of dihydrofolic acid reductase, an enzyme involved in the conversion of dihydrofolic acid to tetrahydrofolic acid. Trimethoprim selectively inhibits the synthesis of bacterial proteins, causing their death. Trimetoprim is effective for most strains of the following bacteria: Bordetella sp., Citrobacter sp., Enterobacter sp., Escherichia coli, Haemophilus influenzae, Hafnia sp., Klebsiella pneumoniae, Legionella sp., Pasteurella sp., Providencia sp., Serratia sp., Salmonella sp., Shigella sp., Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus saprophyticus, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus viridans, Streptococcus faecalis, Vibrio sp. and Yersinia sp.
Indications for use:
Urinary tract infections cause by susceptible strains of Escherichia coli, Proteus mirabilis, Enterobacter sp. and staphylococcus including Staphylococcus saprophyticus. Respiratory tract infections: pneumonia caused by Pneumocystis carinii (also as a complication in the acquired immune deficiency syndrome – AIDS). Gastrointestinal infections: typhoid, diarrhoea caused by E. coli (including traveller’s diarrhea). The sensitivity of bacteria should be demonstrated in tests.